In the Synthesis of 9-fluorenol
#1
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Posted 13 June 2014 - 09:52 PM
ix-fluorenol has been a subject of much interest among nootropics users for quite a while now, e'er since the Cephalon study that suggested the prescription drug Modafinil had simply a few main active metabolites, 1 of them being 9-fluorenol which was reported to exist 39% more constructive than Modafinil alone. Additionally It does non take known toxicity or carcinogenicity in humans.If enough interest is shown I am tempted to purchase a quantity, have it third party purity tested by a lab of the community's choice and brand inquiry packs available to the customs. Please annotate with your interests or concerns.This substance already seems far safer than nigh of the other nootropics that people have bandwagon jumped onto in the past, due to its straight clan with Modafinil.
http://en.wikipedia.org/wiki/Fluorenol (be sure to check out the references at the lesser of the page besides)
#two
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Posted fourteen June 2014 - 12:34 AM
#iii
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Posted 14 June 2014 - 06:12 AM
Me too depending on cost.
#4
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Posted 14 June 2014 - 01:58 PM
I'd be interested in a alanine ester of information technology...
#5
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Posted 14 June 2014 - 06:56 PM
Yes, I would be more interested in that equally well, but I admit I have no hope for guessing pharmacokinetics, so this is the next best thing. My worry with fluorenol is that it needs a quick digesting/converting replacement for the alcohol group to be fully effective so that the liver doesn't oxidize it to something worthless immediately. I wonder if an alanine ester would exist able to be added, then exist completely converted back to the alcohol.
#half dozen
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Posted xiv June 2014 - 08:44 PM
I'grand not that hip on pharmacology, simply I would assume that being that monoamine oxidase wouldn't work on information technology fast because of the secondary carbon next to the amine that it would cleaved down by the esterases dorsum into fluorenol and alanine, wiki says fluorenol isn't considered dangerous, and alanine is a amino acid.
And then my best gauge is it'due south one-half life would exist based on how long it took the esterases to work on it, and with all that carbon at the other end of it, it could very well be extremely potent. lol, I'd take some and let y'all know....
#7
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Posted xiv June 2014 - 09:14 PM
I'd dearest to exercise some experimentation and endeavor it out, just I don't think I desire to exist doing any home synthesis! :P If its already bachelor in a pure form that would be quite highly-seasoned.
#8
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Posted 14 June 2014 - 09:22 PM
Probably right about that, my understanding is that carboxylic acids are only easily esterified via H+ with simple alcohols.....
#9
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Posted 15 June 2014 - 05:15 AM
Concerning the possible liver action or other chemical science getting in the way…..what about sublingual or nasal pathways? There could exist some reason I'yard unaware of. I tried pramiracetam sub lingual in a small amount it was not a good thought. For a while my natural language felt like it does if yous drinkable something that's as well hot for comfort.
Ron
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Posted eighteen June 2014 - 02:54 PM
While I hate how the major drug companies take overly inflated the price of Modafinil in this country, I realized that have a right to exercise this given that they created and patented the "recipe."
So my question to you lot, which is probably going to be hard to answer, is whether you think the drug companies will go after9-fluorenol and somehow claim that, even though it's a metabolite of Modafinil?
I seriously doubt it myself.
#11
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Posted 18 June 2014 - 06:39 PM
This has been discussed earlier, interest kind of died off.
http://www.longecity...e-to-modafinil/
I am as well interested.. could be a safe legal-ish way to go a mod similar substance stateside, at least we would not be importing a controlled substance
#12
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Posted xix June 2014 - 01:xviii AM
No, I really don't recall that could happen considering Its patent expired long ago. It was offset patented in 1939 so no one has a claim on ix-fluorenol as far as I know.
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Posted 19 June 2014 - 05:12 AM
hmm I wonder why some of the noot companies don't selection this upward then? If any applicable patent has expired... anyone could synthesize and sell this stuff? Since it is a metabolite of mod nosotros know it is at least as prophylactic as modern.. which is prissy. Non that I am against a group buy, merely if I could become this from a reputable supplier the group purchase anxiety would be eliminated.
#fourteen
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Posted 19 June 2014 - 06:04 AM
Anytime you can circumvent big pharma I'thou all for information technology. These people are a large part of the money that bought and paid for the decease of single payer wellness intendance. The money is e'er wrong. The insurance companies [ another group of raptors ] helped too. Point is if they tin can throw that kind of money around to subvert democratic process they deserve to be circumvented. That is the very least they deserve…….
Ron
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Posted 13 September 2019 - 02:19 PM
Additionally Information technology does not have known toxicity or carcinogenicity in humans.
I know this an very old thread, but looking to confirm this statement is not possible. There were no human being trials carried out. I guess this claim stems from the wiki-sentence "Its toxicity andcarcinogenicity in humans are unknown" which was misinterpreted. It just says that there is no data yet.
Source: https://www.longecity.org/forum/topic/71364-9-fluorenol-modafinil-alternative/
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